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Eliminan al 100% VPH investigadores del IPN

Con estudios moleculares, el IPN comprobó la eliminación del Virus del Papiloma Humano (VPH), focalizado en el cérvix uterino de 29 mujeres de la Ciudad de México, tratadas con terapia fotodinámica, técnica no invasiva la cual puede ser un método eficaz para prevenir esta neoplasia, que constituye la segunda causa de muerte en mexicanas.

La científica Eva Ramón Gallegos refirió que el estudio también arrojó que mediante esa terapia es posible eliminar las lesiones premalignas de cáncer de cérvix en una etapa inicial.

La investigadora precisó que en la fase clínica se han tratado con esta terapia a 420 pacientes de Oaxaca y Veracruz, además de las 29 de la Ciudad de México, quienes estaban infectadas con el VPH, presentaban lesiones premalignas en el cérvix o tenían ambas afecciones.

En el marco del Día Mundial Contra el Cáncer 2019: Crea un Mundo sin Cáncer Cervicouterino, Ramón Gallegos mencionó que el tratamiento se realizó en dos etapas bajo el mismo número de esquemas diferentes de aplicación de la terapia.

“En la primera parte participaron mujeres de Oaxaca y Veracruz, con resultados alentadores. En la aplicación de la técnica en las capitalinas también tuvo un efecto muy esperanzador, lo que abre la posibilidad de hacer más eficaz el tratamiento, al usar el esquema que se adapte a la situación de las pacientes”, subrayó.

En la terapia, indicó la doctora, se aplica en el cuello del útero un fármaco llamado ácido delta aminolevulínico, que después de cuatro horas se transforma en una sustancia química fluorescente que se acumula en las células dañadas, esto permite eliminar con un rayo láser especial sólo las estructuras impregnadas con ésta.

En la primera parte de la investigación el tratamiento fue aplicado en tres ocasiones con un intervalo de 48 horas cada una, con un tiempo de radiación acorde a cada caso y tipo de lesión.

Los resultados arrojaron que las mujeres que sólo tenían el virus sin lesiones, se eliminó el VPH en 85 por ciento.

Precisó que en las pacientes con lesiones y VPH, el tratamiento tuvo una eficacia de 85 por ciento, además, las mujeres con lesiones sin VPH se logró 42 por ciento de éxito.

En el caso de las mujeres de la Ciudad de México, la investigadora indicó se les aplicó el doble de la concentración de ácido delta aminolevulínico. El tratamiento se realizó dos ocasiones con intervalo de 48 horas.

A este grupo se logró eliminar el VPH en 100 por ciento de las pacientes que lo portaban sin tener lesiones, 64.3 por ciento en las mujeres con VPH y lesiones, y 57.2 por ciento en quienes presentaban lesiones sin VPH.

Antes de someterse a la terapia, libre de efectos secundarios, a las pacientes se les realizaron estudios de colposcopía, papanicolau, captura de híbridos, reacción en cadena de polimerasa y una biopsia para diagnosticar lesiones premalignas o infección con VPH.

“A diferencia de otros tratamientos únicamente elimina las células dañadas y no incide sobre las estructuras sanas. Por ello, tiene gran potencial para disminuir el índice de mortandad por cáncer cervicouterino”, sostuvo.

La especialista añadió que bajo el esquema aplicado a las mujeres capitalinas, también tuvo un efecto positivo en la eliminación de cepas bacterianas patógenas.

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